What are the symptoms of toxic overload, and how can you detox your body naturally? Toxic overload is the condition of having an excessive amount of toxins in one’s body. These harmful substances come from water, food, cleaning products, and other environmental sources to which many people are regularly exposed. If the body fails to flush out these toxins properly, or if the body’s ability to remove toxic waste is overwhelmed by the toxic overload, they can build up over ti